SCN1A Polyclonal Antibody - RA34756

SCN1A Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA34756-50, RA34756-100 Citations, Manuals and MSDS Available upon request. Background: sodium voltage-gated channel alpha subunit 1 (SCN1A) Homo sapiens Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, th Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000 Applications: WB; ELISA Species Cross-Reactivity: Human; Rat GeneID (Human): 6323 Protein MW (KDa): 220 SWISS: P35498 Source: Rabbit Research Use Only