SDHB Monoclonal Antibody - BT-MCA2002

SDHB Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2002-50, BT-MCA2002-100

Citations, Manuals and MSDS Available upon request.

Background: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Research Areas: Signal Transduction, Metabolism

Target Protein: SDHB

Applications: IHC, FCM

Clonality: Monoclonal

Clone ID: 2B2B1

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: SDHB

Immunogen: Purified recombinant fragment of human SDHB (AA: 29-280) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 31.6kDa

UniProt Accession: P21912

Synonyms: IP, SDH, CWS2, PGL4, SDH1, SDH2, SDHIP

GeneID: 6390

Research Use Only