Product Description

SERPINB1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7999-50, BS7999-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P30740

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IF

All Applications: WB: 1:500~1:2000
IF: 1:50~1:200

Background: The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. The monocyte/neutrophil elastase inhibitor gene, SERPINB1, belongs to the Ov-serpin family (ovalbumin-related serpins). Human SerpinB1, also designated monocyte/neutrophil elastase inhibitor (M/NEI) or leukocyte elastase inhibitor (LEI), is a cytoplasmic protein which acts as a fast-acting stoichiometric proteinase inhibitor that regulates the activity of neutrophil elastase (NE), cathepsin-G and proteinase-3. There are four homologous genes in mouse designated SerpinB1a, SerpinB1b, SerpinB1c and the pseudogene, Serpinb1-ps1. The three protein-coding genes share significant sequence identity, however SerpinB1a (also designated EIA) has been characterized as the functional ortholog of human SerpinB1.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SERPINB1 polyclonal antibody detects endogenous levels of SERPINB1 protein.

Bioworld Molecular Weight: ~ 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: WesternBlot (WB) analysis of SERPINB1 polyclonal antibody, Immunofluorescence analysis of Hela cells, using SERPINB1 polyclonal antibody

Alternative Name: Anti elastase;
EI;
ELANH2;
ILEU_HUMAN;
LEI;
Leukocyte elastase inhibitor;
M/NEI;
MNEI;
Monocyte/neutrophil elastase inhibitor;
Peptidase inhibitor 2;
Pi-2;
PI2;
Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 1;
Serpin B1;
Serpin peptidase inhibitor clade B (ovalbumin) member 1;
serpinb1;

Immunogen: Recombinant full length Human SERPINB1.

Conjugate: Unconjugated

Modification: Unmodified