SETD7 Monoclonal Antibody - BT-MCA4089

SETD7 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4089-50, BT-MCA4089-100

Citations, Manuals and MSDS Available upon request.

Background: Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Research Areas: Others

Target Protein: SETD7

Applications: WB, IHC

Reactivity: Human, Rat, Monkey

Clonality: Monoclonal

Clone ID: 3D6G11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: SETD7

Immunogen: Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 40.7kDa

UniProt Accession: Q8WTS6

Synonyms: KMT7, SET7, SET9, SET7/9

GeneID: 80854

Research Use Only