Product Description

SFRP4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10941-50, ES10941-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: SFRP4

Specificity: SFRP4 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in mesenchymal cells, Highly expressed in the stroma of proliferative endometrium, Expressed in cardiomyocytes, Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases, In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level),

Observed Band (KD): 38kD

Fields: Wnt signaling pathway

Function: Disease: Associated with tumor-induced osteomalacia, a disorder in which there is an increase in renal phosphate excretion and a reduction in serum phosphate levels leading to hyperphosphaturia, hypophosphatemia and rickets
Domain: The FZ domain is involved in binding with Wnt ligands
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake
Induction: Increased levels in failing myocardium. Up-regulated in several tumor types including ostomalacia-associated tumors and en

Subcellular Location: Secreted Cytoplasmic in ovarian tumor cells

Storage and Stability: -20°C/1 year

Gene Name: SFRP4 FRPHE

Protein Name: Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)

Mouse SwissProt Number: Q9Z1N6

Rat SwissProt Number: Q9JLS4

Research Use Only