Product Description

SGK1 (Phospho-T256) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67593-50, BS67593-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt . SGK is rapidly induced in response to a variety of stimμli, including serum, glucocorticoid, follicle stimμlating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways . Induction and activation of SGK has been implicated in activating the modμlation of anti-apoptotic and cell cycle regμlation . SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regμlation of processes such as cell survival, neuronal excitability, and renal sodium excretion . SGK is negatively regμlated by ubiquitination and proteasome degradation .

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: SGK, Serine/threonine-protein kinase Sgk1, Serum/glucocorticoid-regμlated kinase 1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SGK1 with a phosphorylation site at T256. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of SGK1 with a phosphorylation site at T256 protein.

Molecular Weight: ~ 45 kDa

Pathway: MTOR signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O00141

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only