Shb Polyclonal Antibody - BT-AP08287

Shb Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP08287-20, BT-AP08287-50, BT-AP08287-100

Citations, Manuals and MSDS Available upon request.

Background: The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell. Specifically, the SH2 domain targets SH2 domain-containing proteins to tyrosine-phosphorylated sites, an event that can trigger a protein-protein interaction cascade which may ultimately effect gene expression and cellular function. Shb (SH2 domain-containing adapter protein b), Shd (SH2 domain-containing adapter protein d), She (SH2 domain-containing adapter protein e) and Shf (SH2 domain-containing adapter protein f) are SH2 domain-containing proteins that play various roles throughout the cell. Shb is a widely expressed protein that localizes to both the cell membrane and the cytoplasm and plays an important role in signal transduction, mainly by linking activated proteins to downstream signaling targets, thereby propagating a signal cascade. Unlike Shb, Shd and Shf are thought to function as adaptor proteins, the former of which may be involved in apoptotic regulation.

Research Areas: Signal Transduction

Target Protein: SHB

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Shb Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 55042

UniProt Accession: Human: Q15464; Mouse: Q6PD21

Synonyms: SHB; SH2 domain-containing adapter protein B

GeneID: Human: 6461; Mouse: 230126

Research Use Only