Product Description

SHPTP1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66607-50, MB66607-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regμlatory domain. SHP-1 removes phosphates from target proteins to downregμlate several tyrosine kinase-regμlated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regμlate hematopoietic growth. Overexpression of SHP-1 in epithelial cells resμlts in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregμlation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R β chain and downregμlates IL-3-induced tyrosine phosphorylation and cell proliferation. Because SHP-1 downregμlates various proliferation pathways, SHP-1 is considered a potential tumor suppressor and angiogenesis regμlator.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IP

Alternate Names: HCP, PTP1C, Tyrosine-protein phosphatase non-receptor type 6, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human SHP-1 protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000), IP (1/10 - 1/50)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of SHPTP1 protein.

Molecular Weight: ~ 63 kDa

Pathway: Jak Stat: IL-6 Receptor Signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P29350

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only