SIGLEC8 Monoclonal Antibody - BT-MCA4447

SIGLEC8 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4447-50, BT-MCA4447-100

Citations, Manuals and MSDS Available upon request.

Background: Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983])

Research Areas: Immunology

Target Protein: SIGLEC8

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 1A5B9

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: SIGLEC8

Immunogen: Purified recombinant fragment of human SIGLEC8 (AA: extra 17-216) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 54kDa

UniProt Accession: Q9NYZ4

Synonyms: SAF2, SIGLEC-8, SIGLEC8L

GeneID: 27181

Research Use Only