Product Description

SIK1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4895-50, ES4895-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: SIK1, SIK, SNF1LK, Serine/threonine-protein kinase SIK1, Salt-inducible kinase 1, SIK-1, Serine/threonine-protein kinase SNF1-like kinase 1, Serine/threonine-protein kinase SNF1LK

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human SIK. AA range:148-197

Isotype: IgG

Target: QIK/QSK

Specificity: SIK1 Polyclonal Antibody detects endogenous levels of SIK1 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Fetal lung, Spleen, Testis,

Observed Band (KD): 85kD

Fields: Glucagon signaling pathway

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein
Cofactor: Magnesium
Enzyme Regulation: Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39
Function: Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily
Similarity: Contains 1 protein kinase domain
Similarity: Contains 1 UBA domain
Subcellular Location: Translocates to the cytoplasm on phosp

Subcellular Location: Cytoplasm Nucleus Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348)

Storage and Stability: -20°C/1 year

Gene Name: SIK1

Protein Name: Serine/threonine-protein kinase SIK1

Mouse SwissProt Number: Q60670

Rat Gene ID: 59329

Rat SwissProt Number: Q9R1U5

Research Use Only