SIRT1 Monoclonal Antibody - BT-MCA1127

SIRT1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1127-50, BT-MCA1127-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined| however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Research Areas: Tags and; cell markers; Microbiology; Metabolism; Cell biology; Epigenetics and nuclear signaling

Target Protein: SIRT1

Applications: WB, IHC-p, IF, ICC, FCM, ELISA

Reactivity: Human,Monkey

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: NAD-dependent deacetylase sirtuin-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q96EB6; Mouse: Q923E4

Synonyms: SIRT1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2

GeneID: Human: 23411

Research Use Only