SIRT1 Monoclonal Antibody - BT-MCA3237

SIRT1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3237-50, BT-MCA3237-100

Citations, Manuals and MSDS Available upon request.

Background: The Sir2 protein in yeast is known to function in transcriptional silencing processes through the deacetylation of histones H3 and H4. The more recently described human homologue of Sir2, known as SIRT1, has been found to associate with the tumor suppressor protein p53.SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription, preventing cellular senescence and apoptosis induced by DNA damage and stress.SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues, with high expression in heart, brain and skeletal muscle and low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.

Research Areas: Cell Biology

Target Protein: SIRT1

Applications: WB, IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1F3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: SIRT1

Immunogen: Purified recombinant fragment of human SIRT1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 120kDa

UniProt Accession: Q96EB6

Synonyms: SIR2L1, SIRT1

GeneID: 23411

Research Use Only