Product Description

SIVA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10565-50, ES10565-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein AA range: 1-50

Isotype: IgG

Target: SIVA

Specificity: SIVA Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Ubiquitous, Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon,

Observed Band (KD): 19kD

Fields: p53 signaling pathway

Function: Cofactor: Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions
Function: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis
pharmaceutical: Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1
PTM: Phosphorylated by ABL2/ARG in response to oxidative stress
Subcellular Location: In the nucleus, accumulates in dot-like structures
Subunit: Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2
t

Subcellular Location: Cytoplasm Nucleus In the nucleus, accumulates in dot-like structures

Storage and Stability: -20°C/1 year

Gene Name: SIVA1 SIVA

Protein Name: Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP)

Mouse SwissProt Number: O54926

Rat SwissProt Number: P59692

Research Use Only