SKP2 Monoclonal Antibody - BT-MCA4418

SKP2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4418-50, BT-MCA4418-100

Citations, Manuals and MSDS Available upon request.

Background: SKP2: S-phase kinase-associated protein 2 (p45). This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms.

Research Areas: Cell Biology

Target Protein: SKP2

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6G9D10

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: SKP2

Immunogen: Purified recombinant fragment of SKP2 (aa1-130) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q13309

Synonyms: FBL1, FLB1, FBXL1, MGC1366, SKP2

GeneID: 6502

Research Use Only