Skp2 p45 Monoclonal Antibody - BT-MCA1128

Skp2 p45 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1128-50, BT-MCA1128-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class| in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and int

Research Areas: Cancer; Cell biology; Cardiovascular

Target Protein: SKP2

Applications: WB, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: S-phase kinase-associated protein 2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q13309; Mouse: Q9Z0Z3

Synonyms: SKP2; FBXL1; S-phase kinase-associated protein 2; Cyclin-A; CDK2-associated protein p45; F-box protein Skp2; F-box; LRR-repeat protein 1; p45skp2

GeneID: Human: 6502

Research Use Only