SMAD6 Monoclonal Antibody - BT-MCA2396

SMAD6 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2396-50, BT-MCA2396-100

Citations, Manuals and MSDS Available upon request.

Background: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.

Research Areas: Signal Transduction

Target Protein: SMAD6

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5H3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: SMAD6

Immunogen: Purified recombinant fragment of human SMAD6 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 53kDa

UniProt Accession: O43541

Synonyms: MADH6, MADH7, HsT17432, SMAD6

GeneID: 4091

Research Use Only