SMAD7 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-63686-60, E-AB-63686-120, E-AB-63686-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: SMAD7
Target Synonym: SMAD7; CRCS3; MADH7; MADH8
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB, IF
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: O15105
Background: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human SMAD7 (NP_005895.1).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000 IF 1:50-1:200
Calculated MW: 23kDa/46kDa
Observed MW: 46kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only