SMC1 Monoclonal Antibody - BT-MCA1142

SMC1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1142-50, BT-MCA1142-100

Citations, Manuals and MSDS Available upon request.

Background: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Altern

Research Areas: Epigenetics and nuclear signaling; Cell biology

Target Protein: SMC1A

Applications: WB

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Structural maintenance of chromosomes protein 1A

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q14683; Mouse: Q9CU62; Rat: Q9Z1M9

Synonyms: SMC1A; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8

GeneID: Human: 8243; Mouse: 24061; Rat: 63996

Research Use Only