Product Description

SMC1A Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB0047-50, MB0047-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interac tion with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb1.8, SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Human recombinant protein fragment corresponding to amino acids 889-1016 of human SMC1A (NP_006297) produced in E.coli.

Dilution: WB: 1:500
IHC: 1:500

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: This antibody detects endogenous levels of SMC1A and does not cross-react with related proteins

Molecular Weight: ~ 143 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q14683

Product: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Research Use Only