SMG7 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A15371-20, A15371-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD) ; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 127kDa
Observed Molecular Weight: 127kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 9887
SWISS: Q92540
Alternate Names: EST1C; SGA56M; C1orf16; SMG7
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:200 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling.
NCBI Alias: SMG7
Research Use Only