SNAI1 Monoclonal Antibody - BT-MCA4792

SNAI1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4792-50, BT-MCA4792-100

Citations, Manuals and MSDS Available upon request.

Background: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: SNAI1

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6D2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: SNAI1

Immunogen: Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 29kDa

UniProt Accession: O95863

Synonyms: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

GeneID: 6615

Research Use Only