SnoN Polyclonal Antibody - BT-AP08426

SnoN Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP08426-20, BT-AP08426-50, BT-AP08426-100

Citations, Manuals and MSDS Available upon request.

Background: Ski-like protein encoded by SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: SKIL

Applications: WB, IHC-p, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: SnoN Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 77004

UniProt Accession: Human: P12757; Mouse: Q60665

Synonyms: SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein

GeneID: Human: 6498; Mouse: 20482

Research Use Only