SORC3 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA34948-50, RA34948-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: sortilin related VPS10 domain containing receptor 3 (SORCS3) Homo sapiens This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid pre Reactivity: Human, Mouse Host: Rabbit Applications: WB, ELISA Clonality: Polyclonal Dilution: WB 1:500-2000 ELISA 1:5000-20000 Molecular Weight: 134 Protein Molecular Weight (kDa): 134 Storage: -20°C/1 year Human Gene ID: 22986 Human SwissProt Number: Q9UPU3 Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Research Use Only