SORL1 Monoclonal Antibody - BT-MCA2474

SORL1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2474-50, BT-MCA2474-100

Citations, Manuals and MSDS Available upon request.

Background: SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Research Areas: Signal transduction, Neuroscience

Target Protein: SORL1

Applications: IHC, ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3B6B11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: SORL1

Immunogen: Purified recombinant fragment of human SORL1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q92673

Synonyms: SORL1

GeneID: 6653

Research Use Only