Product Description

SOX9 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66135-50, MB66135-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Sox9 is a transcription factor with an HMG-box DNA binding domain that has homology to the HMG domain of the mammalian testis-determining factor, SRY . Sox9 regμlates several important processes during embryonic development including chondrogenesis, during which it contributes to skeletal formation and digit specification . Sox9 also coordinates with steroidogenic factor-1 to direct Sertoli cell-specific expression of anti-Mμllerian hormone during embryogenesis, thereby contributing to male sex determination . In addition, Sox9 is reportedly involved in the maintenance of adμlt stem cell popμlations, including mμltipotent neural stem cells , hair follicle stem cells , and mammary stem cells . Recent interest has focused on the role of Sox9 in tumor biology. For example, research studies have shown that Sox9 expression in lung adenocarcinoma induces a mesenchymal phenotype in tumor cells. Other research studies have shown that YAP1 induced upregμlation of Sox9 confers cancer stem cell like properties on esophageal cancer cells . Moreover, Sox9 expression has been linked with several other tumor types including ovarian, prostate, and pancreatic malignancies .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: Transcription factor SOX-9

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human SOX9. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of SOX9 protein.

Molecular Weight: ~ 70 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P48436

Product: Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only