Product Description

SQSTM1 Mouse Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB9009-50, MB9009-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin/TTN downstream signaling in muscle cells and regμlate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regμlation of K+ channels.

Category: Primary Antibody

Reactivity: Human, Monkey, Mouse, Rat

Host: Mouse

Applications: FC, IHC, WB

Alternate Names: Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, p60, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, SQSTM1, ORCA, OSIL

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Fμll length human recombinant protein of human SQSTM1 (NP_003891) produced in HEK293T cell.

Dilution: WB 1:500~2000
IHC 1:150
FLOW 1:100

Purification: Purified from mouse ascites fluids or tissue cμlture supernatant by affinity chromatography (protein A/G).

Specificity: This antibody detects endogenous levels of SQSTM1 and does not cross-react with related proteins.

Molecular Weight: ~ 62 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q13501

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only