SREBP-1 Polyclonal Antibody - BT-AP08553

SREBP-1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP08553-20, BT-AP08553-50, BT-AP08553-100

Citations, Manuals and MSDS Available upon request.

Background: SREBF1 encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. Sterol regulatory element-binding protein 1 is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

Research Areas: Cardiovascular

Target Protein: SREBF1

Applications: WB, IHC-p, ELISA

Reactivity: Human, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: SREBP-1 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 121675

UniProt Accession: Human: P36956; Mouse: Q9WTN3; Rat: P56720

Synonyms: SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1

GeneID: Human: 6720; Rat: 78968

Research Use Only