STAT3 Monoclonal Antibody - BT-MCA2556

STAT3 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2556-50, BT-MCA2556-100

Citations, Manuals and MSDS Available upon request.

Background: The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3

Research Areas: Signal Transduction

Target Protein: STAT3

Applications: IHC, ICC

Reactivity: Human, Mouse, Monkey

Clonality: Monoclonal

Clone ID: 3B5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: STAT3

Immunogen: Purified recombinant fragment of human STAT3 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 88kDa

UniProt Accession: P40763

Synonyms: APRF, HIES, FLJ20882, MGC16063, STAT3

GeneID: 6774

Research Use Only