Product Description

STAT3 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66575-50, MB66575-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Stat3 transcription factor is an important signaling molecμle for many cytokines and growth factor receptors and is required for murine fetal development. Research studies have shown that Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Transcriptional activation seems to be regμlated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Monkey, Hamster

Host: Mouse

Applications: WB

Alternate Names: APRF, Signal transducer and activator of transcription 3, Acute-phase response factor

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human STAT3 protein fragments expressed in E.coli

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of STAT3 protein.

Molecular Weight: ~ 79 kDa

Pathway: ErbB HER Signaling，Jak Stat: IL-6 Receptor Signaling，Inhibition of Apoptosis，Regμlation of Microtubμle Dynamics，SAPK JNK Signaling Cascades

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P40763

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only