Stat5 Monoclonal Antibody - BT-MCA3219

Stat5 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3219-50, BT-MCA3219-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Research Areas: Others

Target Protein: Stat5

Applications: FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7F7A4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: Stat5

Immunogen: Synthesized peptide of human Stat5 (AA: KAVDG[pTyr]VKPQIK).

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide.

Molecular Weight (Da): 90.6kDa

UniProt Accession: P42229

Synonyms: MGF, STAT5A

GeneID: 6776

Research Use Only