Product Description

Stat5b Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS6031-50, BS6031-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Stat5a and Stat5b (signal transducer and activator of transcription 5a and 5b, 96% homology) undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus where they initiate transcription. Activation of Stat5b via IL-2, IL-4, CSF1 and growth hormones influences TCR signaling, apoptosis, adμlt mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with retinoic acid receptor-α gene in acute promyelocytic leukemias (APLL).

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, IF

Alternate Names: Signal transducer and activator of transcription 5B, STA5B, STAT5, Stat5b, Transcription factor STAT5B,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human Stat5b.

Dilution: WB: 1:500~1:2000
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: STAT5B polyclonal antibody detects endogenous levels of STAT5B protein.

Molecular Weight: ~ 90 kDa

Pathway: Immune Cell Signaling, Jak Stat: IL-6 Receptor Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P51692

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only