Stat6 Monoclonal Antibody - BT-MCA1167

Stat6 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1167-50, BT-MCA1167-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Research Areas: Signal transduction; Epigenetics and nuclear signaling; Cancer

Target Protein: STAT6

Applications: WB, IF, ICC, ELISA

Reactivity: Human,Mouse,Rat,Monkey

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Signal transducer and activator of transcription 6

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P42226; Mouse: P52633

Synonyms: STAT6; Signal transducer and activator of transcription 6; IL-4 Stat

GeneID: Human: 6778; Mouse: 20852

Research Use Only