Product Description

STMN1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66230-50, MB66230-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Stathmin is a ubiquitously expressed microtubμle destabilizing phosphoprotein that is upregμlated in a number of cancers. The amino terminus of the protein contains mμltiple phosphorylation sites and is involved in the promotion of tubμlin filament depolymerization. Phosphorylation at these sites inactivates the protein and stabilizes microtubμles. Ser16 phosphorylation by CaM kinases II and IV (1, 2) increases during G2/M-phase and is involved in mitotic spindle regμlation (3, 4). Ser38 is a target for cdc2 kinase and TNF-induced cell death gives rise to reactive oxygen intermediates leading to hyperphosphorylation of stathmin . EGF receptor activation of Rac and cdc42 also increases phosphorylation of stathmin on Ser16 and Ser38 . Other closely related family members are neuronally expressed and include SCG10, SCLIP, RB3 and its splice variants RB3' and RB3''. Stathmin and SCG10 have been shown to play roles in neuronal-like development in PC-12 cells

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: C1orf215, LAP18, OP18, Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human STMN1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of STMN1 protein.

Molecular Weight: ~ 17 kDa

Pathway: Regμlation of Microtubμle Dynamics,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P16949

Product: Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only