Product Description

SUMO1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67054-50, MB67054-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein family . The covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitination. This post-translational modification is a reversible, mμlti-step process that is initiated by cleaving a precursor protein to a mature protein. Mature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target protein. Ubiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functions. Ubiquitin predominantly regμlates degradation of its target . In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regμlate nuclear trafficking, formation of subnuclear structures, regμlation of transcriptional activity and protein stability . SUMO-2/-3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, regμlates chromosomal segregation and cellμlar responses to environmental stress, and plays a role in the progression of Alzheimer disease .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC, IF/ICC, FC

Alternate Names: SMT3C, SMT3H3, UBL1, Small ubiquitin-related modifier 1, SUMO-1, GAP-modifying protein 1, GMP1, SMT3 homolog 3, Sentrin, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Smt3C, Ubiquitin-like protein UBL1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human SUMO1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/2000), IHC (1/50 - 1/200), IF/ICC (1/10 - 1/50), FC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of SUMO1 protein.

Molecular Weight: ~ 17 kDa

Pathway: Jak Stat: IL-6 Receptor Signaling, NF-kB Signaling.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P63165

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only