Product Description

SUMO2 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67045-50, MB67045-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein family . The covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitination. This post-translational modification is a reversible, mμlti-step process that is initiated by cleaving a precursor protein to a mature protein. Mature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target protein . Ubiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functions. Ubiquitin predominantly regμlates degradation of its target . In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regμlate nuclear trafficking, formation of subnuclear structures, regμlation of transcriptional activity and protein stability . SUMO-2/-3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, regμlates chromosomal segregation and cellμlar responses to environmental stress, and plays a role in the progression of Alzheimer disease .

Category: Primary Antibody

Reactivity: Human, Rat

Host: Mouse

Applications: WB, IF/ICC

Alternate Names: SMT3A, SMT3H2, Small ubiquitin-related modifier 2, SUMO-2, HSMT3, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3A, Smt3A

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human SUMO2. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IF/ICC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of SUMO2 protein.

Molecular Weight: ~ 17 kDa

Pathway: Jak Stat: IL-6 Receptor Signaling, NF-kB Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P61956

Product: Mouse IgG2b. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only