Product Description

SUMO3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10849-50, ES10849-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein AA range: 1-50

Isotype: IgG

Target: SUMO3

Specificity: SUMO3 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed predominantly in liver,

Observed Band (KD): 11kD

Fields: Nucleocytoplasmic transport, Fluid shear stress and atherosclerosis

Function: Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4
Online Information: SUMO protein entry,PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function
PTM: Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function
PTM: Polymeric chains can be formed through Lys-11 cross-linking
Similarity: Belongs to the ubiquitin family. S

Subcellular Location: Cytoplasm Nucleus Nucleus, PML body

Storage and Stability: -20°C/1 year

Gene Name: SUMO3 SMT3B SMT3H1

Protein Name: Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3B) (Smt3B)

Mouse SwissProt Number: Q9Z172

Rat SwissProt Number: Q5XIF4

Research Use Only