SYK Monoclonal Antibody - BT-MCA4668

SYK Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4668-50, BT-MCA4668-100

Citations, Manuals and MSDS Available upon request.

Background: SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

Research Areas: Cardiovascular

Target Protein: SYK

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 8C1A3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: SYK

Immunogen: Purified recombinant fragment of SYK (aa296-484) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P43405

Synonyms: FLJ25043, FLJ37489, DKFZp313N1010

GeneID: 6850

Research Use Only