Product Description

SYT14 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10332-50, ES10332-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: synaptotagmin 14(SYT14) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: SYT14,

Specificity: SYT14 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Highly expressed in fetal and adult brain tissue.

Observed Band (KD): 61kD

Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Similarity: Belongs to the synaptotagmin family. Similarity: Contains 2 C2 domains. Subunit: Homodimer. Can also form heterodimers.

Subcellular Location: Membrane, Single-pass type III membrane protein Localized in perinuclear and submembranous regions.

Storage and Stability: -20°C/1 year

Gene Name: SYT14

Protein Name: Synaptotagmin-14, Synaptotagmin XIV, SytXIV

Human Gene ID: 255928

Human SwissProt Number: Q8NB59

Mouse SwissProt Number: Q7TN84

Research Use Only