Product Description

T2R43 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5450-50, ES5450-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: TAS2R43, Taste receptor type 2 member 43, T2R43, Taste receptor type 2 member 52, T2R52

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TAS2R43. AA range:124-173

Isotype: IgG

Target: T2R43

Specificity: T2R43 Polyclonal Antibody detects endogenous levels of T2R43 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells, Expressed in airway epithelia,

Observed Band (KD): 35kD

Fields: Taste transduction

Function: Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds, individual taste cells can discriminate among bitter stimuli
Similarity: Belongs to the G-protein coupled receptor T2R family
Tissue Specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells

Subcellular Location: Membrane, Multi-pass membrane protein Cell projection, cilium membrane In airway epithelial cells, localizes to motile cilia

Storage and Stability: -20°C/1 year

Gene Name: TAS2R43

Protein Name: Taste receptor type 2 member 43

Research Use Only