TAB1 Monoclonal Antibody - BT-MCA1181

TAB1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1181-50, BT-MCA1181-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr

Research Areas: Signal transduction; Cardiovascular; Immunology

Target Protein: TAB1

Applications: WB

Reactivity: Human,Mouse,Rat,Bovine,Dog,Pig

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q15750; Mouse: Q8CF89

Synonyms: TAB1; MAP3K7IP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1

GeneID: Human: 10454; Mouse: 66513

Research Use Only