Product Description

TAZ Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS71120-50, BS71120-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Transcriptional coactivator which acts as a downstream regμlatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regμlatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regμlatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regμlation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumμlation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regμlates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: WW domain-containing transcription regμlator protein 1, Transcriptional coactivator with PDZ-binding motif, TAZ, WWTR1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human TAZ(NP_056287.1).

Dilution: WB, 1:500 - 1:2000 IHC, 1:50 - 1:200 IF/ICC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Polyclonal Antibodies

Molecular Weight: 55KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9GZV5

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only