TBL1XR1 Monoclonal Antibody - BT-MCA1187

TBL1XR1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1187-50, BT-MCA1187-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.

Research Areas: Epigenetics and nuclear signaling; Cancer; Metabolism

Target Protein: TBL1XR1

Applications: WB, IHC-p, IF, ICC

Reactivity: Human,Mouse,Rat,Bovine,Chicken,Dog,Pig,Zebrafish

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: F-box-like,WD repeat-containing protein TBL1XR1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9BZK7; Mouse: Q8BHJ5

Synonyms: TBL1XR1; IRA1; TBLR1; F-box-like; WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor; HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1

GeneID: Human: 79718; Mouse: 81004

Research Use Only