Product Description

TCAM2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11113-50, ES11113-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: TIRP is a Toll/interleukin-1 receptor (IL1R, MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4, MIM 603030).[supplied by OMIM, Apr 2004],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: TCAM2

Specificity: TCAM2 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1),

Observed Band (KD): 25kD

Fields: NF-kappa B signaling pathway, Necroptosis, Toll-like receptor signaling pathway, Pertussis, Hepatitis B, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis

Function: Domain: The TIR domain mediates the interaction with TRAF6
Function: Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1
PTM: Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling
PTM: Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation
Similarity: Belongs to the EMP24/GP25L family
Similarity: Contains 1 GOLD domain
Similarity: Contains 1 TIR domain
Subcellular Location: Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion

Subcellular Location: [Isoform 1]: Cytoplasm Golgi apparatus Cell membrane Endoplasmic reticulum Early endosome membrane Late endosome membrane Cell projection, phagocytic cup Localized to the plasma membrane as a result of myristoylation Phosphorylation on Ser-16 leads to its depletion from the membrane Upon LPS stimulation colcoalizes with isoform 2 in late endosomes, [Isoform 2]: Endoplasmic reticulum Early endosome membrane Late endosome membrane Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1

Storage and Stability: -20°C/1 year

Gene Name: TICAM2 TIRAP3 TIRP TRAM

Protein Name: TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor doma

Mouse SwissProt Number: Q8BJQ4

Research Use Only