TCF7 Monoclonal Antibody - BT-MCA3117

TCF7 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3117-50, BT-MCA3117-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: TCF7

Applications: IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1B4E9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TCF7

Immunogen: Purified recombinant fragment of human TCF7 (AA: 168-358) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 41.6kDa

UniProt Accession: P36402

Synonyms: TCF-1

GeneID: 6932

Research Use Only