Product Description

TEL Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5183-50, ES5183-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: ETV6, TEL, TEL1, Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Tel. AA range:223-272

Isotype: IgG

Target: TEL

Specificity: TEL Polyclonal Antibody detects endogenous levels of TEL protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous,

Observed Band (KD): 55kD

Fields: Transcriptional misregulation in cancer

Function: Disease: A chromosomal aberration involving ETV6 is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM: 131440]. Translocation t(5, 12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein
Disease: A chromosomal aberration involving ETV6 is a cause of acute lymphoblastic leukemia. Translocation t(9, 12)(p13, p13) with PAX5
Disease: A chromosomal aberration involving ETV6 is a cause of myelodysplastic syndrome (MDS). Translocation t(1, 12)(p36.1, p13) with MDS2
Disease: A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5, 12)(q33, p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML)
Disease: A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: ETV6

Protein Name: Transcription factor ETV6

Mouse SwissProt Number: P97360

Research Use Only