Product Description

Tet1 (C-term) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ12161-50, BZ12161-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q3URK3

Host: Rabbit

Reactivity: Mouse

Applications: WB

All Applications: WB: 1:2000

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Anti-Tet1 Antibody (C-term)at 1:2000 dilution + F9 whole cellLysatesLysates/proteins at 20 µg per lane.

Bioworld Molecular Weight: ~ 219 kDa

Specificity: Tet1 (C-term) polyclonal antibody detects endogenous levels of Tet1 protein.

Alternative Name: Methylcytosine dioxygenase TET1; CXXC-type zinc finger protein 6; Ten-eleven translocation 1 gene protein homolog; Cxxc6; Kiaa1676

Immunogen: This mouse Tet1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1845-1879 amino acids from the C-terminal region of mouse Tet1.

Conjugate: Unconjugated

Modification: Unmodified