TIP60 Monoclonal Antibody - BT-MCA3840

TIP60 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3840-50, BT-MCA3840-100

Citations, Manuals and MSDS Available upon request.

Background: HTATIP (HIV-1 Tat interacting protein TIP60, about 60kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Research Areas: Others

Target Protein: TIP60

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3F9

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: TIP60

Immunogen: Purified recombinant fragment of human TIP60 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 60kDa

UniProt Accession: Q92993

Synonyms: TIP60 (HTATIP)

GeneID: 10524

Research Use Only