Product Description

TIP60 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4497-50, ES4497-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: IHC, IF, ELISA

Alternate Names: KAT5, HTATIP, TIP60, Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TIP60. AA range:52-101

Isotype: IgG

Target: TIP60

Specificity: TIP60 Polyclonal Antibody detects endogenous levels of TIP60 protein.

Dilution: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain,

Molecular Weight (Da): 59kD

Fields: Spinocerebellar ataxia, Human T-cell leukemia virus 1 infection

Function: negative regulation of transcription from RNA polymerase II promoter, regulation of cytokine production, negative regulation of cytokine production, DNA metabolic process, DNA repair, double-strand break repair, chromatin organization, chromatin assembly or disassembly, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid acetylation, response to DNA damage stimulus,DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,intracellular signaling cascade, negative regulation of biosynthetic process, positive regulation of biosynthetic process,regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, neg

Subcellular Location: Nucleus Chromosome Cytoplasm Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole Nucleus, nucleolus Cytoplasm, perinuclear region Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386) Transiently localizes to kinetochores in early mitosis (PubMed:26829474) Localizes to spindle poles when chromosomes align during metaphase (PubMed:34608293) Localizes in the cytoplasm and nucleus of round spermatids (By similarity)

Storage and Stability: -20°C/1 year

Gene Name: KAT5

Protein Name: Histone acetyltransferase KAT5

Mouse Gene ID: 81601

Mouse SwissProt Number: Q8CHK4

Research Use Only