Product Description

TLK1 (phospho-S743) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64008-50, BS64008-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Tousled-like kinases (TLK1 and TLK2, also designated PKU-β and PKU-α, respectively) are the human homologs of the Tousled gene from Arabidopsis thaliana, which encodes a Serine/Threonine kinase that is necessary for proper organ morphogenesis. Both TLKs contain a nuclear localization signal and a predicted coiled-coil region in the N-terminal domain. TLK is ubiquitously expressed, and is prevalent in mouse testis, especially in pachytene spermatocytes and round spermatids. It displays a propensity to dimerize through an interaction between its coiled-coil structure and is able to autophosphorylate, as well as phosphorylate exogenous substrates. TLK1 and TLK2 are regμlated by the cell cycle, showing maximum activity during S phase. Subsequently, they are thought to regμlate the development of mμlticellμlar organisms, including playing a key role in spermatogenesis, through a series of phosphorylations.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Serine/threonine-protein kinase tousled-like 1, PKU-beta, Tousled-like kinase 1, TLK-1, KIAA0137, PKU-β, PKU β, PKUβ

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human TLK1 around the phosphorylation site of Serine 743.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-TLK1 (S743) polyclonal antibody detects endogenous levels of TLK1 protein only when phosphorylated at Ser743.

Molecular Weight: ~ 86 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UKI8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only