TLR2 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA35342-50, RA35342-100 Citations, Manuals and MSDS Available upon request. Background: toll like receptor 2 (TLR2) Homo sapiens The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs) . Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016], Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. Storage Instructions: -20°C/1 year Recommended dilutions: IHC: 1:200-500 Alternative Names: TLR2; TIL4; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282; YM3391 Applications: IHC-p; IF (paraffin section) Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 7097 SWISS: O60603 Source: Rabbit Research Use Only